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PMC:2065877 JSONTXT

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div. section text # proj. length # Ann.
0 TIAB EBV Latent Membrane Protein 1 Activates Akt, NFκB, and Stat3 in B Cell Lymphomas Latent membrane pro 23 962 163 show
1 Introduction Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus that infects humans predominantly at an early 18 4923 858 show
2 Results High Levels of LMP1 Expression Correlates with the Development of Lymphoma LMP1 expression in IgLMP1 18 1783 286 show
3 Results LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion To determine if LMP1 signaling affect 18 3049 573 show
4 Results LMP1 Promotes B Cell Survival and Proliferation In Vitro Primary B cell cultures can be maintained t 18 2927 0 show
5 Results Wild-Type and LMP1 Transgenic Lymphoma Cells Do Not Require IL4 and Stat6 Signaling To investigate w 18 1612 293 show
6 Results LMP1 Upregulates IL10 and Constitutively Activates Stat3 To identify cytokines that may contribute t 18 3724 633 show
7 Results LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway LMP1 transformation of rodent 18 3501 594 show
8 Results LMP1 Promotes Tumor Growth and Survival through Activation of Akt, NFκB, and Stat3 Pathways To explo 18 4331 789 show
9 Discussion This study defines the oncogenic properties of LMP1 in promoting B cell lymphomagenesis. LMP1 transg 18 8385 1440 show
10 Materials and Methods Transgenic mice. Generation of LMP1 mice under the Ig heavy chain promoter and enhancer have been de 18 852 142 show
11 Materials and Methods Isolation and growth of B cells. Splenocytes were prepared by homogenizing spleen tissue with two fr 18 1033 185 show
12 Materials and Methods MTS assay. The 3-(4, 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazo 18 1417 276 show
13 Materials and Methods Immunohistochemistry. Paraffin-embedded spleen sections were deparaffinized in Histoclear (National 18 965 178 show
14 Materials and Methods Flow cytometry. One million splenocytes were stained with the appropriate primary antibody unconjuga 18 721 132 show
15 Materials and Methods Rnase protection assay. Total RNA was isolated from CD19+ MACS-purified B cells using the Rneasy mid 18 1066 201 show
16 Materials and Methods PCR analysis of κ chain rearrangement. DNA was isolated from splenocytes using the Dneasy Tissue Kit 18 507 125 show
17 Materials and Methods Immunoblot analysis. Whole cell lysates were prepared in radioimmunoprecipitation assay (RIPA) buffe 18 943 168 show
18 Materials and Methods Antibodies. FITC-conjugated goat anti-mouse IgM, rat IgG2aκ anti-mouse IgD (clone 11–26), rat IgG1κ 18 1125 214 show
19 Caption-Figure 1 High LMP1 Expression Correlates with the Development of Lymphoma LMP1 expression is shown by (A) imm 18 540 109 show
20 Caption-Figure 2 LMP1 Promotes B-1a Lymphomas That Can Escape Allelic Exclusion (A) Flow cytometry analysis of spleno 18 968 213 show
21 Caption-Figure 3 LMP1 Promotes B Cell Survival and Proliferation In Vitro (A) MTS assay of splenocytes from WT and LM 18 902 182 show
22 Caption-Figure 4 Wild-Type and LMP1 Transgenic Lymphoma Cells Survive Independently of IL4/Stat6 Signaling in Culture 18 1032 203 show
23 Caption-Figure 5 LMP1 Upregulates IL10 Expression and Constitutively Activates Stat3 (A) Relative expression of IL10, 18 1023 211 show
24 Caption-Figure 6 LMP1 Activates Akt Signaling and Deregulates the Rb Cell Cycle Pathway (A and B) Immunoblot analysis 18 656 131 show
25 Caption-Figure 7 Akt, NFκB, and Stat3 Signaling Are Required for the Growth and Survival of Lymphoma Cells MTS assay 18 710 156 show
26 Caption-Figure 8 Analysis of Akt, NFκB, and Stat3 Pathways in Contribution to the Growth and Survival of Lymphoma Cel 18 486 101 show
27 Caption-Table 1 Summary of Analysis Performed on Wild-Type and LMP1 Transgenic Lymphomas 18 72 10 show