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PMC:1064873 JSONTXT

Divisions (17) JSON TSV
 

div. section text # proj. length # Ann.
0 TIAB Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytoki 35 1667 279 show
1 Introduction IL-10 is a key cytokine in regulating inflammatory responses, mainly by inhibiting the production an 28 5317 910 show
2 Materials and methods Patients and samples The total patient population consisted of 32 patients with RA (25 women and sev 28 1167 215 show
3 Materials and methods Isolation of CD4+ T cells Peripheral blood mononuclear cells (PBMC) were prepared from heparinized b 28 1076 205 show
4 Materials and methods Culture of CD4+ T cells PB CD4+ T-cell populations were resuspended at a density of 1 × 106 cells/ml 24 1045 210 show
5 Materials and methods Flow cytometric analysis for IL-10R1 expression A sample of 5 × 105 cells of PBMC was resuspended in 28 636 114 show
6 Materials and methods Immunoassay for IFN-γ and IL-2 Concentrations of IFN-γ and IL-2 in culture supernatants of CD4+ T ce 28 389 63 show
7 Materials and methods Isolation of mRNA and real-time PCR Total cellular RNA was extracted from PB CD4+ T cells using an R 28 1521 343 show
8 Materials and methods Western blot analysis CD4+ T cells were stimulated for 20 min by the indicated concentrations of IL- 28 1828 336 show
9 Materials and methods Statistical analysis Data are expressed as the mean value ± standard error of the mean or box plots. 28 276 49 show
10 Results Resistance to IL-10 inhibition of IFN-γ production in RA CD4+ T cells The CD28 costimulatory pathway 28 2329 449 show
11 Results Increased expression of cell surface IL-10R1 on RA CD4+ T cells The functional receptor complex of I 28 847 155 show
12 Results Defective IL-10-mediated STAT3 phosphorylation in RA CD4+ T cells The interaction of IL-10R with IL- 28 1453 251 show
13 Results IL-6-mediated STAT3 phosphorylation and inhibition of IL-10 effect in normal CD4+ T cells STAT3 is a 28 2444 440 show
14 Results High expression of SOCS1 mRNA in RA CD4+ T cells IL-6 induces two potent inhibitors of JAKs (SOCS1 a 28 1341 250 show
15 Discussion CD4+ T cells orchestrate the Th1-type cell-mediated immune response in RA [22]. Activated CD4+ T cel 28 11138 1949 show
16 Conclusion CD4+ T cells from active RA patients are characterized by their resistance to IL-10 inhibition of IF 28 990 171 show