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PMC:1079843 JSONTXT

Divisions (16) JSON TSV
 

div. section text # proj. length # Ann.
0 TIAB Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene(TPH1)and associatio 3 2316 0 show
1 Background Bipolar affective disorder (BPD) is a chronic, severe mood disorder characterized by recurrent episo 3 5193 0 show
2 Methods Subjects Since 1998, probands were recruited from bipolar outpatients in the Chung Shan Medical Univ 3 1643 0 show
3 Methods DNA preparation Approximately 10 ml of peripheral blood was collected from the recruits using EDTA a 3 269 0 show
4 Methods Primer design for searching for, and typing of, TPH1 gene polymorphisms All primers used were design 3 917 0 show
5 Methods SNP identification in the coding and regulatory regions of the TPH1 gene In order to identify all SN 3 2927 0 show
6 Methods Selection of SNP markers for the TPH1 gene In addition to the SNPs identified in the present study, 3 672 0 show
7 Methods SNP genotyping Except for the intron 7 A218C polymorphism, which was genotyped using a modified Ampl 3 1906 0 show
8 Methods Statistical analysis The chi-squared test for allelic and genotypic distributions between patients a 3 1317 0 show
9 Results Detection of TPH1 gene polymorphisms in the Taiwanese Han population To detect SNPs in the human TPH 3 796 0 show
10 Results SNP genotyping and single locus association analysis For further association analysis, all 5 SNPs id 3 877 0 show
11 Results Pairwise linkage disequilibrium (LD) measurement and haplotype analyses The size of the human TPH1 g 3 2382 0 show
12 Results Haplotype tag selection Selecting haplotype-tag SNPs (ht-SNPs) can systematically and efficiently re 3 779 0 show
13 Discussion The involvement of the TPH1 gene in the pathogenesis of affective disorder is supported by several l 3 7286 0 show
14 Conclusion Bipolar disorder is a complex genetic disorder with a spectrum of phenotype is associated with bipol 3 987 0 show
15 Pre-publication history The pre-publication history for this paper can be accessed here: 3 64 0 show