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Divisions (15)
 

div. section text # proj. length # Ann.
0 TIAB The Two-Component Regulatory System VicRK is Important to Virulence ofStreptococcus equiSubspecieseq 2 1034 35 show
1 INTRODUCTION Bacterial pathogens produce many two-component regulatory systems to regulate gene expression by spe 2 2848 50 show
2 MATERIALS AND METHODS Bacterial Strains and Growth S. equi strain SEM1 was isolated in 2003 from a horse with strangles in 2 296 0 show
3 MATERIALS AND METHODS Generation of a vicK Deletion Mutant A vicK deletion mutant (ΔvicK) of S. equi SEM1 was generated by 2 1089 0 show
4 MATERIALS AND METHODS S. equi Growth in Rabbit Blood S. equi strains were harvested at the exponential growth phase, washe 2 523 0 show
5 MATERIALS AND METHODS Phagocytosis Assay Phagocytosis assay was performed as described previously [6, 20]. Briefly, S. equ 2 765 0 show
6 MATERIALS AND METHODS Mouse Infections S. equi strains were harvested at exponential phase, washed with DPBS, and inoculat 2 738 0 show
7 MATERIALS AND METHODS Enzyme-linked Immunosorbant Assay (ELISA) and Western Blotting Analysis Relative levels of anti-SeM 2 1362 0 show
8 RESULTS S. equi vicK Deletion Mutant The S. equi vicRK genes were found by blasting the S. equi genome datab 2 1639 34 show
9 RESULTS Growth of ΔvicK in THY and Rabbit Blood The growth curve of the ΔvicK mutant in THY displays a longe 2 880 13 show
10 RESULTS No Effect of the vicK Deletion on Resistance of S. equi to Phagocytosis by PMNs To determine whether 2 1161 25 show
11 RESULTS Attenuation of S. equi Virulence by vicK Deletion Group of 8 mice were subcutaneously inoculated wit 2 659 18 show
12 RESULTS ΔvicK Infection Confers Protection of Mice against Reinfection with Wild-Type S. equi To test whethe 2 486 14 show
13 RESULTS Intranasal ΔvicK Infection Induces SeM-Specific Mucosal IgA and Systemic IgG To examine the humoral 2 986 33 show
14 DISCUSSION VicK is essential in B. subtilis [2] and S. aureus [3] but not in S. pneumoniae [7], S. mutans [8], 2 2085 62 show